Circulating Cell-Free Chromatin Particles Trigger a Unique Biphasic STING Signaling Program that Drives DNA Damage and Inflammation

Cell-free chromatin particles from dying cells enter immune cells and activate STING in a biphasic pattern, linking cell death to DNA damage and sterile inflammation—a mechanism with deep roots in the biology of stress and adaptation.

Three things to remember

• Circulating cfChPs enter immune cells within minutes.
• Early STING nuclear trafficking precedes DNA damage; later phosphorylation drives inflammation.
• Blocking STING halts both waves, suggesting a therapeutic target.

Source

This signal is based on Circulating Cell-Free Chromatin Particles Trigger a Unique Biphasic STING Signaling Program that Drives DNA Damage and Inflammation from bioRxiv immunology and cell biology. Read the original report for full context.

Health note: Preprint, in vitro only; human relevance unproven.