A 516-sample, 13-tissue proteomic map across five decades exposes transcriptome-proteome decoupling, amyloid accumulation, and tissue-specific aging clocks—with blood vessels aging earliest and a plasma signature tracing organ origins.
Three things to remember
- Proteostasis declines with age, marked by amyloid buildup and mRNA-protein decoupling.
- Blood vessels age early and are highly susceptible, with inflection around 50.
- Plasma proteomic signature mirrors tissue aging; GAS6 emerges as candidate senoprotein.
Source
This signal is based on Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures. from PubMed. Read the original report for full context.
Health note: Cross-sectional design infers trajectories; clinical relevance of senoproteins requires validation.