Dihydromyricetin, a natural flavonoid, acts as a senomorphic in fibroblasts by boosting PRDX2 nuclear translocation for DNA repair, and as a senolytic in microglia by disrupting mitochondrial function—offering a dual mechanism to combat age-related decline.
Three things to remember
- Dihydromyricetin protects senescent fibroblasts from DNA damage and reduces SASP.
- It promotes PRDX2 nuclear translocation to facilitate DNA repair in senescent cells.
- In microglia with low PRDX2, it triggers apoptosis via mitochondrial impairment.
Source
This signal is based on The natural flavonoid dihydromyricetin targets senescent cells via PRDX2 and alleviates age-related diseases. from PubMed. Read the original report for full context.
Health note: Preclinical findings in mice and cells; human efficacy and safety unproven.