A new class of energy-metabolism-engaged nanomedicines (EM-eNMs) infiltrates mitochondria, triggers fission and mitophagy, and restores stemness in aged bone marrow cells, reversing osteoporotic bone loss in mice.
Three things to remember
- EM-eNMs bind ATP synthase, inducing DRP1-mediated mitochondrial fission.
- Systemic delivery selectively targets bone, reversing osteoporosis in aged mice.
- Mechanism parallels caloric restriction, activating mitophagy to clear damaged mitochondria.
Source
This signal is based on An energy metabolism-engaged nanomedicine maintains mitochondrial homeostasis to alleviate cellular ageing. from PubMed. Read the original report for full context.
Health note: Preclinical study in mice; human efficacy and safety unproven.