Experiments in cells and aged mice traced part of the inflammatory output of senescent cells to mitochondrial citrate metabolism. Inhibiting the transporter SLC25A1 reduced inflammatory signalling without making the cells resume division.
Three things to remember
- Mitochondrial citrate supplied material that helped switch inflammatory genes on.
- Blocking SLC25A1 reduced inflammatory signals in laboratory and mouse experiments.
- No human treatment was tested, and SLC25A1 is not a consumer target.
Source
This signal is based on Blocking a mitochondrial transporter may curb inflammation from ‘zombie’ cells without killing them from Medical Xpress Healthy Aging.
Primary study: Nature — Mitochondrial metabolism and epigenetic crosstalk drive the SASP.
Health note: These mechanistic findings come from cell and mouse research. They do not establish the safety or effectiveness of blocking this pathway in people.